Li Charles, Li Linda, Keates Andrew C
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Oncotarget. 2012 Apr;3(4):365-70. doi: 10.18632/oncotarget.490.
Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using external magnetic fields, and also allows simultaneous imaging to monitor the delivery in vivo. Compared to conventional gene delivery strategies, this technique has been shown to significantly increase gene delivery to human xenograft tumors models, as well as various internal organs (e.g. liver, kidney) and the central nervous system. Magnetic nanoparticle technology, therefore, has the potential to turn the challenge of gene therapy in vivo into a new frontier for cancer treatment.
癌症基因组学的最新进展为通过直接靶向致病基因来治疗癌症开辟了无限潜力。然而，为了将这种潜力转化为对患者具有临床可行性的治疗方法，需要新的递送方法。磁性纳米颗粒技术提供了通过使用外部磁场实现治疗性基因选择性和高效递送的潜力，并且还允许同时进行成像以监测体内递送情况。与传统的基因递送策略相比，该技术已被证明能显著提高向人异种移植肿瘤模型以及各种内部器官（如肝脏、肾脏）和中枢神经系统的基因递送。因此，磁性纳米颗粒技术有潜力将体内基因治疗的挑战转变为癌症治疗的新前沿。
