气相中的对映选择性超分子器件。间苯二酚[4]芳烃作为模型体系。

Enantioselective supramolecular devices in the gas phase. Resorcin[4]arene as a model system.

机构信息

Sapienza University of Rome, Department of Chemistry and Technologies of Drug, Piazzale Aldo Moro, 5, 00185, Rome, Italy.

出版信息

Beilstein J Org Chem. 2012;8:539-50. doi: 10.3762/bjoc.8.62. Epub 2012 Apr 12.

DOI:10.3762/bjoc.8.62

PMID:22563353

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3343281/

Abstract

This review describes the state-of-art in the field of the gas-phase reactivity of diastereomeric complexes formed between a chiral artificial receptor and a biologically active molecule. The presented experimental approach is a ligand-displacement reaction carried out in a nano ESI-FT-ICR instrument, supported by a thermodynamic MS-study and molecular-mechanics and molecular-dynamics (MM/MD) computational techniques. The noncovalent ion-molecule complexes are ideal for the study of chiral recognition in the absence of complicating solvent and counterion effects.

摘要

本文综述了手性人工受体与生物活性分子形成的非对映异构体配合物在气相反应性领域的最新进展。所提出的实验方法是在手性识别过程中，在纳米电喷雾傅里叶变换离子回旋共振（ESI-FT-ICR）仪器中进行的配体取代反应，通过热力学 MS 研究以及分子力学和分子动力学（MM/MD）计算技术得到支持。非共价离子-分子配合物是研究手性识别的理想模型，因为它们可以避免复杂的溶剂和抗衡离子效应。