预测体外受精女性妊娠结局的血清生物标志物：胚胎移植后11天的人绒毛膜促性腺激素、孕酮和抑制素A水平。
Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET.
作者信息
Kim Jee Hyun, Shin Mi Sun, Yi Gwang, Jee Byung Chul, Lee Jung Ryeol, Suh Chang Suk, Kim Seok Hyun
机构信息
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea.
出版信息
Clin Exp Reprod Med. 2012 Mar;39(1):28-32. doi: 10.5653/cerm.2012.39.1.28. Epub 2012 Mar 31.
OBJECTIVE
This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF.
METHODS
Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis.
RESULTS
For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010).
CONCLUSION
A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.
目的
本研究旨在评估体外受精（IVF）患者胚胎移植（ET）后11天测定的血清人绒毛膜促性腺激素（hCG）、孕酮和抑制素A水平对预测妊娠结局的预后价值。
方法
2005年5月至2008年4月期间，收集了70例行IVF-ET的不孕女性在ET后11天的血清并保存。采用商用酶联免疫吸附测定试剂盒检测hCG、孕酮和抑制素A水平。通过受试者操作特征曲线分析计算hCG、孕酮和抑制素A水平对确立宫内妊娠和持续妊娠的预测准确性。
结果
对于宫内妊娠和持续妊娠的预测，血清hCG优于孕酮和抑制素A。孕酮和抑制素A的预测性能相似。血清孕酮和抑制素A水平显著相关（r=0.915，p=0.010）。
结论
单次测定血清hCG水平足以预测IVF-ET患者的妊娠结局。
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