Naredi Nikita, Singh S K, Sharma Rajesh
Assisted Reproductive Technology Centre, Command Hospital, Pune, Maharashtra, India.
Department of Obstetrics & Gynaecology, Command Hospital, Pune, Maharashtra, India.
J Hum Reprod Sci. 2017 Apr-Jun;10(2):108-113. doi: 10.4103/jhrs.JHRS_50_16.
Pregnancies achieved through fertilisation (IVF) are associated with adverse first trimester outcomes in comparison to spontaneously achieved pregnancies. In view of this, it is imperative to predict the success as well as prognosticate the pregnancy outcome of an IVF cycle not only for the clinicians but also the couples undergoing IVF. Serum beta-human chorionic gonadotropin (β-hCG) value has, thus, been used as a biomarker for pregnancy outcome after IVF and also an aid in counselling and management of the patient.
The main objective of this study was to compare the predictive value of the first serum β-hCG value and the pregnancy outcome after an IVF cycle (whether fresh or frozen embryo transfer) in the two subgroups of patients.
The study was conducted at Assisted Reproductive Technology Centre of a tertiary care hospital, and it was a retrospective cohort study.
A retrospective study was performed for post-IVF pregnancies at a single IVF centre from March 2014 to February 2015 with serum β-hCG values less than or equal to 1000 mIU/ml. The initial serum values of β-hCG on the day 16 of embryo transfer were correlated with first trimester pregnancy outcome and ongoing pregnancy rate (>12 weeks gestation).
Of the 208 post-IVF pregnancies included in the study, the group with β-hCG more than 500 mIU/ml had statistically significant higher ongoing pregnancy rates and a lesser poor pregnancy outcome.
The study concluded that an early serum β-hCG value can be used as a predictor of a successful or an adverse first trimester pregnancy outcome helping in better counselling and monitoring of the high-risk precious IVF pregnancies.
与自然受孕相比，通过体外受精（IVF）实现的妊娠与孕早期不良结局相关。鉴于此，不仅对于临床医生，而且对于接受IVF的夫妇来说，预测IVF周期的成功率以及推断妊娠结局都至关重要。因此，血清β-人绒毛膜促性腺激素（β-hCG）值已被用作IVF后妊娠结局的生物标志物，也有助于对患者进行咨询和管理。
本研究的主要目的是比较两组患者中首次血清β-hCG值的预测价值以及IVF周期（无论是新鲜胚胎移植还是冷冻胚胎移植）后的妊娠结局。
本研究在一家三级护理医院的辅助生殖技术中心进行，是一项回顾性队列研究。
对2014年3月至2015年2月在单个IVF中心进行的IVF后妊娠且血清β-hCG值小于或等于(1000 mIU/ml)的患者进行回顾性研究。胚胎移植第16天的初始血清β-hCG值与孕早期妊娠结局及持续妊娠率（妊娠>12周）相关。
在本研究纳入的208例IVF后妊娠中，β-hCG大于(500 mIU/ml)的组持续妊娠率在统计学上显著更高，不良妊娠结局更少。
该研究得出结论，早期血清β-hCG值可作为孕早期妊娠成功或不良结局的预测指标，有助于对高危珍贵IVF妊娠进行更好的咨询和监测。
