Pahwa Rakesh, Singh Manisha, Kumar Vipin, Kohli Kanchan
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.
Recent Pat Drug Deliv Formul. 2012 Dec;6(3):278-90. doi: 10.2174/187221112802652660.
Gastroretentive drug delivery technology has emerged as an efficient approach for enhancing the bioavailability and controlled delivery of various therapeutic molecules. Myriad of patents issued in the vistas of gastroretentive technology have inspired scientific community worldwide to develop more innovative strategies for the fabrication of drug delivery devices which can be retained in stomach for a controlled period of time. The present paper describes various recent efforts and technological advancements of gastroretentive drug delivery systems along with potential advantages and available marketed preparations. Numerous significant patents concerning gastroretentive drug delivery devices are also highlighted.
胃滞留型药物递送技术已成为提高各种治疗性分子生物利用度和实现控释的有效方法。胃滞留技术领域颁发的大量专利激发了全球科学界开发更具创新性的策略，以制造能够在胃中保留一段可控时间的药物递送装置。本文介绍了胃滞留型药物递送系统的各种最新研究成果和技术进展，以及其潜在优势和市售制剂。还重点介绍了许多与胃滞留型药物递送装置相关的重要专利。
