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[临床试验结果以及苏联制备的人重组干扰素α-2(利福隆)在医学实践中的应用前景]

[The results of clinical trials and the prospects of using the Soviet preparation of human recombinant interferon alpha-2 (reaferon) in medical practice].

作者信息

Kalinin Iu T, Vorob'ev A A, Bumialis V V, Denisov L A, Parfenov V V, Klenova A V, Ianulaĭtis A A, Ershov F I, Marchenko V I, Malinovskaia V V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1990 Sep(9):61-7.

PMID:2256404
Abstract

The results of the clinical trials of human recombinant interferon alpha-2 (reaferon) make it possible to come to the conclusion that the preparation is well-tolerated and produces a pronounced therapeutic effect in a number of viral and oncological diseases. The Pharmacological Committee of the USSR has recommended reaferon for use in acute hepatitis B, hairy cell leukemia, renal cancer at stage IV, disseminated sclerosis, ocular herpes. The use of reaferon has been found to be promising in the treatment of papillomatosis of the larynx, Kaposi's sarcoma, mycosis fungoides, chronic myeloleukemia.

摘要

人重组干扰素α-2(干复津)的临床试验结果表明,该制剂耐受性良好,对多种病毒性疾病和肿瘤疾病具有显著的治疗效果。苏联药理学委员会已推荐干复津用于治疗急性乙型肝炎、毛细胞白血病、IV期肾癌、播散性硬化症、眼部疱疹。已发现干复津在治疗喉乳头状瘤病、卡波西肉瘤、蕈样肉芽肿、慢性粒细胞白血病方面具有应用前景。

相似文献

1
[The results of clinical trials and the prospects of using the Soviet preparation of human recombinant interferon alpha-2 (reaferon) in medical practice].[临床试验结果以及苏联制备的人重组干扰素α-2(利福隆)在医学实践中的应用前景]
Zh Mikrobiol Epidemiol Immunobiol. 1990 Sep(9):61-7.
2
[Recombinant alpha-interferon (reaferon) in the treatment of patients with chronic myeloleukemia].
Ter Arkh. 1990;62(7):41-7.
3
[The results of preclinical trials of the Soviet recombinant preparation of human interferon alpha-2 (reaferon)].[苏联重组人α-2干扰素制剂(利夫罗芬)的临床前试验结果]
Zh Mikrobiol Epidemiol Immunobiol. 1990 Jun(6):93-7.
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[A comparative analysis of the effect of alpha 2-interferon (reaferon) therapy on the morphofunctional state of the bone marrow in patients with chronic myeloleukemia].[α2干扰素(利法隆)治疗对慢性粒细胞白血病患者骨髓形态功能状态影响的比较分析]
Gematol Transfuziol. 1993 Mar;38(3):11-3.
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[Therapeutic effectiveness of the Russian drug reaferon in hairy cell leukemia].
Gematol Transfuziol. 1990 Jun;35(6):16-9.
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[Experience with the use of reaferon (alfa 2-interferon) for treating patients with chronic myeloleukemia].[使用重组干扰素(α2干扰素)治疗慢性粒细胞白血病患者的经验]
Ter Arkh. 1995;67(6):59-63.
7
[Use of interferon inducers and reaferon in the combined therapy of acute viral hepatitis B].[干扰素诱导剂及重组干扰素在急性乙型病毒性肝炎联合治疗中的应用]
Ter Arkh. 1988;60(11):29-32.
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Cell sensitivity to reaferon in patients with renal cell cancer after reaferon therapy.重组干扰素治疗后肾细胞癌患者对重组干扰素的细胞敏感性。
Bull Exp Biol Med. 2007 Jul;144(1):80-2. doi: 10.1007/s10517-007-0260-2.
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[The use of interferon-alfa (reaferon) in patients with chronic myeloleukemia].
Ter Arkh. 1996;68(10):44-7.
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[Recombinant human alfa2-interferon (reaferon) in ointment form in the treatment of various diseases of the skin and mucosa].[重组人α2干扰素(利分能)软膏剂治疗皮肤及黏膜多种疾病]
Antibiot Khimioter. 1990 Sep;35(9):38-40.

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