Isupov I V, Nazarova L S, Pavlova L P, Gor'kova A V, Revazova E S, Dushkin V A, Zadumina S Iu, Surikov N N, Taranenko T M, Dzhaparidze M N
Zh Mikrobiol Epidemiol Immunobiol. 1990 Sep(9):85-9.
Immunization with live plague vaccine has been shown to give no protection to thymectomized mice from subcutaneous challenge with Y. pestis virulent strain. Under the action of the vaccine or individual Y. pestis antigens (fraction I) the functional and morphological activation of thymocytes and macrophages is observed, more pronounced in C57BL/6 mice and less pronounced in CBA mice. Y. pestis antigenic preparations (fractions I and II, pesticin) act as T-cell mitogens and are thus capable of inducing the in vitro proliferation of thymocytes. At the same time the in vivo action of fraction II induces a decrease in the level of lymphocytes in the peripheral blood of mice and the destruction of lymphocytes in their thymus and spleen.
已证明，用活鼠疫疫苗免疫不能保护经胸腺切除的小鼠免受鼠疫耶尔森氏菌强毒株的皮下攻击。在疫苗或单个鼠疫耶尔森氏菌抗原（组分I）的作用下，可观察到胸腺细胞和巨噬细胞的功能和形态激活，在C57BL/6小鼠中更明显，在CBA小鼠中则不太明显。鼠疫耶尔森氏菌抗原制剂（组分I和II、鼠疫菌素）作为T细胞有丝分裂原，因此能够诱导胸腺细胞的体外增殖。同时，组分II的体内作用会导致小鼠外周血淋巴细胞水平降低以及其胸腺和脾脏中的淋巴细胞破坏。
