Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
Clin Exp Hypertens. 2012;34(4):297-304. doi: 10.3109/10641963.2012.681087. Epub 2012 May 7.
We identified the factors associated with home blood pressure (BP) variability in 1933 patients treated with hypertensive drugs (mean age, 67 years; women, 55%). Multivariate regression analysis showed that female gender, advanced age, home BP value, and home heart rate variability were positively associated with home BP variability, whereas home heart rate, body mass index, and duration of antihypertensive treatment were negatively associated with home BP variability. Moreover, not being medicated with amlodipine and being medicated with angiotensin II receptor blockers were associated with increased home systolic BP variability only among patients who were treated for less than 12 months.
我们在 1933 名接受降压药物治疗的患者（平均年龄 67 岁，女性占 55%）中确定了与家庭血压变异性相关的因素。多变量回归分析显示，女性、高龄、家庭血压值和家庭心率变异性与家庭血压变异性呈正相关，而家庭心率、体重指数和降压治疗持续时间与家庭血压变异性呈负相关。此外，在治疗时间少于 12 个月的患者中，未服用氨氯地平和服用血管紧张素 II 受体阻滞剂仅与家庭收缩压变异性增加相关。
