Ushigome E, Fukui M, Hamaguchi M, Tanaka T, Atsuta H, Mogami S-i, Oda Y, Yamazaki M, Hasegawa G, Nakamura N
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Immunology Frontier Research Center at Osaka University, Osaka, Japan.
J Hum Hypertens. 2014 Oct;28(10):594-9. doi: 10.1038/jhh.2014.2. Epub 2014 Feb 6.
Recent studies have shown that variability in home blood pressure has an important role in the progression of organ damage. The objective of this study was to investigate the factors that affect variability in home blood pressure in patients with type 2 diabetes. We assessed the relationship between home blood pressure variability, defined as coefficient of variation of mean of triplicate morning and evening blood pressure for 14 consecutive days, and various factors using univariate and multivariate linear regression analyses in 1114 patients with type 2 diabetes. Age (β=0.149, P<0.001), female sex (β=0.125, P=0.010), duration of diabetes mellitus (β=0.103, P=0.005), heart rate (β=0.136, P<0.001), current smoker (β=0.118, P=0.005), white-coat hypertension (β=0.136, P=0.002) and treatment with calcium channel blockers (β=-0.094, P=0.024) were independently associated with coefficient of variation of morning systolic blood pressure. Our findings implicate that factors that might be intervened such as heart rate, smoking status, use of antihypertensive medication in addition to age, sex and duration of diabetes mellitus are associated with variability in home blood pressure in patients with type 2 diabetes.
近期研究表明，家庭血压变异性在器官损害进展中起重要作用。本研究的目的是调查影响2型糖尿病患者家庭血压变异性的因素。我们在1114例2型糖尿病患者中，使用单因素和多因素线性回归分析评估了家庭血压变异性（定义为连续14天早晚血压均值的变异系数）与各种因素之间的关系。年龄（β=0.149，P<0.001）、女性（β=0.125，P=0.010）、糖尿病病程（β=0.103，P=0.005）、心率（β=0.136，P<0.001）、当前吸烟者（β=0.118，P=0.005）、白大衣高血压（β=0.136，P=0.002）以及使用钙通道阻滞剂治疗（β=-0.094，P=0.024）均与早晨收缩压变异系数独立相关。我们的研究结果表明，除年龄、性别和糖尿病病程外，心率、吸烟状况、抗高血压药物使用等可能可干预的因素与2型糖尿病患者的家庭血压变异性相关。
