自噬与对乙酰氨基酚肝毒性：Atg7基因缺陷小鼠有多大用处？ - Suppr

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Autophagy and acetaminophen hepatotoxicity: how useful are Atg7-deficient mice?

作者信息

Jaeschke Hartmut, Ding Wen-Xing

出版信息

J Gastroenterol. 2012 Jul;47(7):845-6; author reply 847-8. doi: 10.1007/s00535-012-0606-z. Epub 2012 May 8.

DOI:10.1007/s00535-012-0606-z

PMID:22565638

Abstract

摘要

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Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.丙型肝炎病毒结构蛋白可加重或减轻对乙酰氨基酚诱导的小鼠肝损伤。

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Liver autophagy in anorexia nervosa and acute liver injury.神经性厌食症与急性肝损伤中的肝脏自噬

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本文引用的文献

Loss of autophagy promotes murine acetaminophen hepatotoxicity.自噬缺失促进了小鼠对乙酰氨基酚的肝毒性。

J Gastroenterol. 2012 Apr;47(4):433-43. doi: 10.1007/s00535-011-0500-0. Epub 2011 Nov 29.

Activation of autophagy protects against acetaminophen-induced hepatotoxicity.自噬的激活可防止对乙酰氨基酚引起的肝毒性。

Hepatology. 2012 Jan;55(1):222-32. doi: 10.1002/hep.24690. Epub 2011 Dec 6.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.当前对乙酰氨基酚肝毒性的问题——一种用于测试天然产物疗效的临床相关模型。

Life Sci. 2011 Apr 25;88(17-18):737-45. doi: 10.1016/j.lfs.2011.01.025. Epub 2011 Feb 4.

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy.线粒体功能障碍和氧化应激介导了自噬破坏所引发的生理损伤。

Aging (Albany NY). 2009 Apr 9;1(4):425-37. doi: 10.18632/aging.100038.

Comprehensive proteomics analysis of autophagy-deficient mouse liver.自噬缺陷小鼠肝脏的综合蛋白质组学分析

Biochem Biophys Res Commun. 2008 Apr 11;368(3):643-9. doi: 10.1016/j.bbrc.2008.01.112. Epub 2008 Feb 4.

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.自噬缺陷小鼠中，p62的稳态水平控制着细胞质包涵体的形成。

Cell. 2007 Dec 14;131(6):1149-63. doi: 10.1016/j.cell.2007.10.035.

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.对乙酰氨基酚诱导肝细胞死亡的细胞内信号传导机制。

Toxicol Sci. 2006 Jan;89(1):31-41. doi: 10.1093/toxsci/kfi336. Epub 2005 Sep 21.

Acetaminophen-induced oxidant stress and cell injury in cultured mouse hepatocytes: protection by N-acetyl cysteine.对乙酰氨基酚诱导的培养小鼠肝细胞氧化应激和细胞损伤：N-乙酰半胱氨酸的保护作用。

Toxicol Sci. 2004 Aug;80(2):343-9. doi: 10.1093/toxsci/kfh151. Epub 2004 Apr 28.

Mode of cell death after acetaminophen overdose in mice: apoptosis or oncotic necrosis?对乙酰氨基酚过量给药后小鼠的细胞死亡模式：凋亡还是胀亡性坏死？

Toxicol Sci. 2002 Jun;67(2):322-8. doi: 10.1093/toxsci/67.2.322.

Biphasic modulation of acetaminophen bioactivation and hepatotoxicity by pretreatment with the interferon inducer polyinosinic-polycytidylic acid.用干扰素诱导剂聚肌苷酸-聚胞苷酸预处理对乙酰氨基酚生物活化和肝毒性的双相调节作用

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