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本文引用的文献

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Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapy.开始抗逆转录病毒治疗后的第一个月内，女性患生殖器溃疡疾病的风险增加。
J Acquir Immune Defic Syndr. 2009 Dec;52(5):600-3. doi: 10.1097/QAI.0b013e3181b065cf.
2
Disorders of immune reconstitution in patients with HIV infection responding to antiretroviral therapy.接受抗逆转录病毒治疗的HIV感染患者的免疫重建障碍
Curr HIV/AIDS Rep. 2007 Feb;4(1):16-21. doi: 10.1007/s11904-007-0003-z.
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Chronic vulval ulceration--another immune reconstitution inflammatory syndrome?慢性外阴溃疡——另一种免疫重建炎症综合征？
Int J STD AIDS. 2005 Jun;16(6):454-5. doi: 10.1258/0956462054094051.
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Immune reconstitution in HIV-infected patients.HIV感染患者的免疫重建
Clin Infect Dis. 2004 Apr 15;38(8):1159-66. doi: 10.1086/383034. Epub 2004 Apr 5.
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The immune reconstitution inflammatory syndrome.免疫重建炎症综合征
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Clinical indicators of immune restoration following highly active antiretroviral therapy.高效抗逆转录病毒治疗后免疫重建的临床指标
Clin Infect Dis. 2002 Jan 15;34(2):224-33. doi: 10.1086/323898. Epub 2001 Dec 4.
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Immune restoration disease after the treatment of immunodeficient HIV-infected patients with highly active antiretroviral therapy.免疫缺陷的HIV感染患者接受高效抗逆转录病毒治疗后出现的免疫重建疾病。
HIV Med. 2000 Mar;1(2):107-15. doi: 10.1046/j.1468-1293.2000.00012.x.
8
Chronic erosive herpes simplex virus infection of the penis, a possible immune reconstitution disease.阴茎慢性糜烂性单纯疱疹病毒感染，一种可能的免疫重建疾病。
HIV Med. 1999 Oct;1(1):10-8. doi: 10.1046/j.1468-1293.1999.00003.x.
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Gynecologic infections in human immunodeficiency virus-infected women.
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一名治疗失败患者出现难治性慢性外阴溃疡，表现为免疫重建炎症综合征：病例观察

Intractable chronic vulval ulceration presenting as immune reconstitution inflammatory syndrome in a treatment-failure patient: a case observation.

作者信息

Katusiime Christine, Ocama Ponsiano, Kambugu Andrew

机构信息

Department of Prevention, Care and Treatment, Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda.

出版信息

Case Rep Obstet Gynecol. 2011;2011:896964. doi: 10.1155/2011/896964. Epub 2011 Sep 22.

DOI:10.1155/2011/896964
PMID:22567519
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3335519/
Abstract

HIV-1 treatment-failure patients are increasingly being initiated on second-line antiretroviral therapy. The case we describe is of a treatment-failure patient who developed intractable chronic vulval ulceration presenting as immune reconstitution inflammatory syndrome (IRIS), following complete viral suppression with second-line highly active antiretroviral treatment (HAART). To the best of our knowledge, this is the first reported case of intractable vulval ulceration IRIS in an HIV-1 treatment-failure patient.

摘要

越来越多的HIV-1治疗失败患者开始接受二线抗逆转录病毒疗法。我们所描述的病例是一名治疗失败患者，在接受二线高效抗逆转录病毒治疗（HAART）实现病毒完全抑制后，出现了顽固性慢性外阴溃疡，表现为免疫重建炎症综合征（IRIS）。据我们所知，这是首例关于HIV-1治疗失败患者出现顽固性外阴溃疡型IRIS的报告病例。