Smyth A, Gaffney G, Hickey D, Lappin D, Reddan D, Dunne F
Department of Endocrinology, Galway University Hospitals, Galway, Ireland.
Case Rep Obstet Gynecol. 2011;2011:983592. doi: 10.1155/2011/983592. Epub 2011 Jul 10.
The effect of pregnancy on simultaneous pancreas-kidney transplant recipients has previously been described, but experience is limited. We describe the case of a thirty-five-year-old female who previously underwent simultaneous pancreas-kidney transplant for type 1 diabetes mellitus-complicated nephropathy. An integrated multidisciplinary team including the transplant team, nephrologist, endocrinologist, and obstetrician closely followed progress during pregnancy. Blood glucose levels and HbA1c remained within normal limits, and she did not require insulin treatment at any point. She experienced deterioration in renal indices and underwent an uncomplicated, elective Caesarean section at thirty-week gestation. She delivered a male infant of 1.18 kg, appropriate for gestational age, who had hypothermia and respiratory distress, which required intubation and ventilation and an eleven-week stay in the special care baby unit. At eighteen-month followup the infant shows normal development, and there has been no deterioration in either grafts' function.
妊娠对同期胰肾联合移植受者的影响此前已有描述，但经验有限。我们描述了一名35岁女性的病例，她此前因1型糖尿病合并肾病接受了同期胰肾联合移植。一个由移植团队、肾病学家、内分泌学家和产科医生组成的综合多学科团队在孕期密切跟踪其病情进展。血糖水平和糖化血红蛋白（HbA1c）均保持在正常范围内，她在孕期任何时候都不需要胰岛素治疗。她的肾功能指标出现恶化，并在妊娠30周时接受了一次顺利的择期剖宫产。她产下一名体重1.18千克、孕周相符的男婴，该男婴体温过低且有呼吸窘迫，需要插管和通气，并在新生儿重症监护病房住院11周。在18个月的随访中，婴儿发育正常，移植器官的功能均未恶化。
