Vibo R, Schneider S, Kõrv J
Department of Neurology and Neurosurgery, University of Tartu, 51014 Tartu, Estonia.
Stroke Res Treat. 2012;2012:731570. doi: 10.1155/2012/731570. Epub 2012 Apr 10.
The aim of this paper was to evaluate the long-term survival of young stroke patients in Estonia, analyse time trends of survival, and compare the results with other studies. We have used 2 population-based first-ever stroke registry data (1991-1993 and 2001-2003) to analyse the 1-, 5-, and 7-year outcome of young stroke patients by the Kaplan-Meier method of analysis. From the group of 1206 patients, 129 (11%) were aged under 55 years. The overall survival rate at 1, 5, and 7 years was 0.70 (95% CI 0.62-0.78), 0.63 (95% CI 0.55-0.72), and 0.61 (95% CI 0.53-0.70), respectively. The survival was significantly worse for patients with intracerebral haemorrhage (P < 0.01) and for those aged from 45 to 54 years compared to the younger age group from 0 to 44 years (P = 0.03). For patients with ischemic stroke, aged from 15 to 44 years, the 1-, 5-, and 7-year survival rate was 0.89 (95% CI 0.79-1.00), 0.75 (95% CI 0.61-0.93), and 0.75 (0.61-0.93), respectively. There was no difference in overall survival between the two studied periods. We report a low long-term survival rate among young stroke patients in Estonia. Increasing age and hemorrhagic stroke subtype were associated with lower survival. We have previously shown a worse outcome for 1-year survival compared to other studies and currently this trend continues for 5- and 7-year survival rates. In fact, these are the lowest survival rates for the combined and separate stroke subtypes reported so far.
本文旨在评估爱沙尼亚年轻卒中患者的长期生存率，分析生存时间趋势，并将结果与其他研究进行比较。我们使用了2组基于人群的首次卒中登记数据（1991 - 1993年和2001 - 2003年），通过Kaplan - Meier分析方法分析年轻卒中患者1年、5年和7年的预后情况。在1206例患者中，129例（11%）年龄在55岁以下。1年、5年和7年的总体生存率分别为0.70（95%可信区间0.62 - 0.78）、0.63（95%可信区间0.55 - 0.72）和0.61（95%可信区间0.53 - 0.70）。脑出血患者的生存率明显较差（P < 0.01），45至54岁患者的生存率与0至44岁的较年轻年龄组相比也较差（P = 0.03）。对于15至44岁的缺血性卒中患者，1年、5年和7年的生存率分别为0.89（95%可信区间0.79 - 1.00）、0.75（95%可信区间0.61 - 0.93）和0.75（0.61 - 0.93）。两个研究时期的总体生存率没有差异。我们报告爱沙尼亚年轻卒中患者的长期生存率较低。年龄增加和出血性卒中亚型与较低的生存率相关。我们之前显示1年生存率的预后比其他研究差，目前这种趋势在5年和7年生存率中仍在持续。事实上，这些是迄今为止报告的合并及单独卒中亚型的最低生存率。
