Burgova E N, Tkachev N A, Vanin A F
Biofizika. 2012 Jan-Feb;57(1):105-9.
It has been shown that the administration of 0,5 ml of 5 mM aqueous solution of dinitrosyl-iron complexes (DNIC) with cysteine alleviated the development of experimental endometriosis in rats induced by surgical way: the size of endometriomes decreased 1.85 times when the DNIC was added every day during 10 days. The effect was suggested to be due to cytotoxic action of NO molecules and nitrosonium ions (NO+) released from rapidly decomposed DNIC in animal organism on endometriome tissues.
已经表明,给大鼠腹腔注射0.5毫升5毫摩尔/升的二亚硝基铁配合物(DNIC)与半胱氨酸的水溶液,可缓解手术诱导的大鼠实验性子宫内膜异位症的发展:在10天内每天添加DNIC时,子宫内膜瘤的大小减小了1.85倍。据推测,这种作用是由于动物体内快速分解的DNIC释放的NO分子和亚硝基离子(NO+)对子宫内膜瘤组织的细胞毒性作用。