Elsayed Hesham, Sany Dawlat, Eldin Essam Nour, El-shahawy Yasser, Shawki Sahar, Aziz Ahmed
Division of the Renal Disease, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Saudi J Kidney Dis Transpl. 2012 May;23(3):461-6.
In some renal allograft recipients, anemia persists or develops following transplantation. Anemia is associated with pre-operative blood loss and allograft dysfunction, including delayed graft function, acute rejection and chronic allograft dysfunction. To study the prevalence and association of post-renal transplant anemia, we studied 200 renal transplant recipients; 131 (65.5%) patients were males and 69 (34.5%) patients were females, and age ranged from 17 to 67 years, with a mean of 37.7 ± 10.8 years. All patients were receiving cyclosporine, prednisolone and mycophenolate mofetil (MMF). Complete blood count was done at two times: three and six months post-renal transplant. There were 74% anemic patients three months after renal transplantation and 45% anemic patients six months after renal transplantation. High creatinine value, female gender, delayed graft function, episodes of acute rejection, perioperative blood loss and infections were the only significant independent risk factors for prevalence of anemia post-renal transplant. In our study, we did not find an association between MMF and cyclosporine nor angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin receptors blocker (ARBs) with anemia. This study demonstrates that anemia is a common complication during the first six months after kidney transplantation, with several risk factors precipitating this complication.
在一些肾移植受者中，贫血在移植后持续存在或出现。贫血与术前失血和移植肾功能障碍有关，包括移植肾功能延迟恢复、急性排斥反应和慢性移植肾功能障碍。为了研究肾移植后贫血的患病率及相关性，我们对200例肾移植受者进行了研究；其中131例（65.5%）为男性，69例（34.5%）为女性，年龄在17至67岁之间，平均年龄为37.7±10.8岁。所有患者均接受环孢素、泼尼松龙和霉酚酸酯（MMF）治疗。在肾移植后的3个月和6个月这两个时间点进行全血细胞计数。肾移植后3个月时有74%的患者贫血，6个月时有45%的患者贫血。高肌酐值、女性性别、移植肾功能延迟恢复、急性排斥反应发作、围手术期失血和感染是肾移植后贫血患病率的仅有的显著独立危险因素。在我们的研究中，我们未发现MMF与环孢素之间、血管紧张素转换酶抑制剂（ACEI）或血管紧张素受体阻滞剂（ARB）与贫血之间存在关联。本研究表明，贫血是肾移植后前6个月内的常见并发症，有多种危险因素促成了这一并发症。
