食管鳞状细胞癌中肿瘤抑制基因的启动子甲基化
Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma.
作者信息
Li Ji-Sheng, Ying Jian-Ming, Wang Xiu-Wen, Wang Zhao-Hui, Tao Qian, Li Li-Li
机构信息
Department of Chemotherapy, Shandong University, Jinan, Shandong, People's Republic of China.
出版信息
Chin J Cancer. 2013 Jan;32(1):3-11. doi: 10.5732/cjc.011.10381. Epub 2012 May 8.
Abstract
Esophageal squamous cell carcinoma (ESCC) is a prevalent and fatal cancer in China and other Asian countries. Epigenetic silencing of key tumor suppressor genes (TSGs) is critical to ESCC initiation and progression. Recently, many novel TSGs silenced by promoter methylation have been identified in ESCC, and these genes further serve as potential tumor markers for high-risk group stratification, early detection, and prognosis prediction. This review summarizes recent discoveries on aberrant promoter methylation of TSGs in ESCC, providing better understanding of the role of disrupted epigenetic regulation in tumorigenesis and insight into diagnostic and prognostic biomarkers for this malignancy.
摘要
食管鳞状细胞癌（ESCC）在中国和其他亚洲国家是一种常见且致命的癌症。关键肿瘤抑制基因（TSG）的表观遗传沉默对ESCC的发生和发展至关重要。最近，在ESCC中已鉴定出许多因启动子甲基化而沉默的新型TSG，这些基因进一步可作为高危人群分层、早期检测和预后预测的潜在肿瘤标志物。本综述总结了ESCC中TSG启动子异常甲基化的最新发现，有助于更好地理解表观遗传调控紊乱在肿瘤发生中的作用，并为这种恶性肿瘤的诊断和预后生物标志物提供见解。
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