Barcelona Centre for International Health Research, CRESIB, Hospital Clinic-University of Barcelona, Barcelona, Spain.
Chemotherapy. 2012;58(2):123-8. doi: 10.1159/000337062. Epub 2012 May 10.
Bloodstream infections are a significant cause of neonatal morbidity and death. An increase in the incidence of early neonatal sepsis due to Escherichia coli has been reported. The objective was to evaluate the antimicrobial resistance of E. coli strains causing early-onset neonatal sepsis (EONS) and late-onset neonatal sepsis (LONS) and their evolution.
E. coli strains from EONS and hospital-acquired LONS collected at the Hospital Clinic of Barcelona were included in the study.
No statistically significant differences in resistance profiles were found between strains causing EONS and LONS. An increase in the resistance to all the antimicrobial agents studied was observed for the period 2000-2008 in comparison with the 1985-1999 period, with the increase in resistance to gentamicin, piperacillin and tobramycin being statistically significant. Two strains carried the bla(CTX-M) genes (bla(CTX-M-14) and bla(CTX-M-15)).
The increase in ampicillin and gentamicin resistance makes a change in the treatment of neonates necessary.
血流感染是导致新生儿发病和死亡的重要原因。据报道，由于大肠杆菌，早发性新生儿败血症（EONS）的发病率有所增加。本研究旨在评估引起早发性新生儿败血症（EONS）和晚发性新生儿败血症（LONS）的大肠杆菌菌株的抗菌药物耐药性及其变化。
本研究纳入了巴塞罗那临床医院收集的 EONS 和医院获得性 LONS 的大肠杆菌菌株。
EONS 和 LONS 致病菌株的耐药谱无统计学差异。与 1985-1999 年相比，2000-2008 年所有研究抗菌药物的耐药性均增加，其中庆大霉素、哌拉西林和妥布霉素的耐药性增加具有统计学意义。有两株菌携带 bla(CTX-M)基因（bla(CTX-M-14)和 bla(CTX-M-15)）。
氨苄西林和庆大霉素耐药性的增加使得新生儿的治疗需要改变。
