Department of Geriatric Medicine, Bezmialem Vakif University, Istanbul, Turkey.
Am J Alzheimers Dis Other Demen. 2012 May;27(3):171-4. doi: 10.1177/1533317512442999.
Cholinesterase inhibitors (ChEIs) are widely used for the treatment of Alzheimer's disease (AD); however, their cholinergic side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the side effects caused by donepezil, rivastigmine, and galantamine on cardiac rhythm and postural blood pressure changes in elderly patients with AD.
Of 204 consecutive elderly patients who were newly diagnosed with AD, 162 were enrolled and underwent comprehensive geriatric assessments. The electrocardiographs (ECGs) and blood pressures were recorded at the baseline and 4 weeks after the dose of 10 mg/d of donepezil, 10 cm(2)/d of rivastigmine, and 24 mg/d of galantamine.
There were no changes relative to the baseline in any of the ECG parameters or arterial blood pressure with any of the administered ChEIs.
It was demonstrated that none of the 3 ChEIs were associated with increased negative chronotropic, arrhythmogenic, and hypotensive effects for the elderly patients with AD.
胆碱酯酶抑制剂（ChEIs）广泛用于治疗阿尔茨海默病（AD）；然而，它们对心血管系统的胆碱能副作用尚不清楚。在这项研究中，我们旨在研究多奈哌齐、加兰他敏和利斯的明对老年 AD 患者的心律和体位血压变化的副作用。
对 204 例新诊断为 AD 的连续老年患者进行了综合老年评估，其中 162 例患者接受了治疗。在服用多奈哌齐 10mg/d、利斯的明 10cm²/d 和加兰他敏 24mg/d 的第 4 周，记录心电图（ECG）和血压。
与基线相比，任何一种 ChEI 治疗都没有改变任何心电图参数或动脉血压。
结果表明，3 种 ChEI 均不会引起老年 AD 患者的负变时性、心律失常和低血压作用增加。
