[PIM-1在前列腺癌组织中的表达及其与前列腺特异性抗原复发的关系]

[Expression of PIM-1 in prostate cancer tissue and its relationship with PSA recurrence].

作者信息

Zhang Chun-Ting, Xu Yong, Luo Fei, Zhang Zhi-Hong, Liu Ran-Lu, Yang Kuo, Ma Bao-Jie

机构信息

Department of Urology, The Second Hospital of Tianjin Medical University/Tianjin Research Institute of Urology, Tianjin 300211, China.

出版信息

Zhonghua Nan Ke Xue. 2012 Apr;18(4):323-6.

PMID:22574367

Abstract

OBJECTIVE

To explore the expression of the PIM-1 protein in prostate cancer tissue and its relationship with PSA recurrence.

METHODS

We used the immunohistochemical SP method to detect the expression of the PIM-1 protein in the prostate tissues of 68 cases of prostate cancer (PCa) and 37 cases of benign prostatic hyperplasia (BPH).

RESULTS

The positive rate of the PIM-1 protein expression was 67.65% (46/68) in the PCa tissue, significantly higher than 40.54% (15/37) in the BPH tissue (P<0.05). Its positive rates in PCa Gleason scores 6, 7 and 8-10 were 33.33% (7/21), 77.5% (21/28) and 94.74% (18/19), respectively, with significant between-group differences (P<0.05), and those in stages I , II, III and IV of PCa were 47.62%, 53.85%, 73.33% and 94.74%, respectively. Kaplan-Meier analysis of the results of a 36-month follow-up showed the ratios of PIM-1 expression to PSA recurrence and non-recurrence were 10/22 (45.45%) and 36/46 (78.26%), respectively, with statistically significant differences (P<0.05).

CONCLUSION

PIM-1 protein expression in PCa tissue is closely related to the Gleason score and clinical stage of PCa and PSA recurrence, which suggests that the PIM-1 gene plays an important role in PCa evolution and progression, and may be an indicator for the prognosis of PCa.

摘要

目的

探讨PIM-1蛋白在前列腺癌组织中的表达及其与前列腺特异抗原（PSA）复发的关系。

方法

采用免疫组织化学SP法检测68例前列腺癌（PCa）组织和37例良性前列腺增生（BPH）组织中PIM-1蛋白的表达。

结果

PCa组织中PIM-1蛋白表达阳性率为67.65%（46/68），显著高于BPH组织中的40.54%（15/37）（P<0.05）。其在PCa Gleason评分6、7和8-10中的阳性率分别为33.33%（7/21）、77.5%（21/28）和94.74%（18/19），组间差异有统计学意义（P<0.05），在PCa的Ⅰ、Ⅱ、Ⅲ和Ⅳ期分别为47.62%、53.85%、73.33%和94.74%。对36个月随访结果进行Kaplan-Meier分析显示，PIM-1表达与PSA复发和未复发的比例分别为10/22（45.45%）和36/46（78.26%），差异有统计学意义（P<0.05）。