Gastrointestinal and Liver Diseases Research Centre, Guilan University of Medical Sciences, Guilan, Islamic Republic of Iran.
East Mediterr Health J. 2012 Mar;18(3):236-40. doi: 10.26719/2012.18.3.236.
The hepatitis C virus (HCV) infection among patients undergoing haemodialysis is high. The aim of this study was to identify the HCV genotypes among chronic haemodialysis patients who were HCV positive in Guilan province, northern Islamic Republic of Iran. All patients on haemodialysis at Guilan haemodialysis centres were enrolled. Enzyme-linked immunosorbent assay and polymerase chain reactio testing were performed. Out of 514 enrolled patients, 11.9% were serologically HCV positive and 6.2% had positive HCV-RNA. HCV genotypes were determined with HCV genotype-specific primers. The most frequent genotypes were 1a (59.4%) and 3a (40.6%). There was no significant relationship between virus genotypes and sex or age. The HCV genotype pattern among haemodialysis patients in Guilan province was different from other countries of the Middle East and was more similar to North American and European countries where genotype 1 is predominant.
在接受血液透析的患者中，丙型肝炎病毒（HCV）感染率很高。本研究旨在确定伊朗北部吉兰省 HCV 阳性的慢性血液透析患者中的 HCV 基因型。所有在吉兰血液透析中心接受血液透析的患者均被纳入研究。采用酶联免疫吸附试验和聚合酶链反应检测。在纳入的 514 名患者中，11.9%的患者血清 HCV 阳性，6.2%的患者 HCV-RNA 阳性。采用 HCV 基因型特异性引物确定 HCV 基因型。最常见的基因型为 1a（59.4%）和 3a（40.6%）。病毒基因型与性别或年龄之间无显著关系。吉兰省血液透析患者的 HCV 基因型模式与中东其他国家不同，与北美和欧洲国家更为相似，这些国家以基因型 1 为主。
