Ten Have-Opbroek A A, Hammond W G, Benfield J R
Department of Pulmonology, University of Leiden, The Netherlands.
Cancer Lett. 1990 Dec 17;55(3):177-82. doi: 10.1016/0304-3835(90)90116-f.
Adenocarcinomas induced in canine bronchial segments placed subcutaneously have bronchiolo-alveolar regions. Immunocytochemistry and routine staining of adjacent sections strongly suggests that the lining of these regions consists of type II cells. These regions may thus represent true prospective alveolar regions, as also seen in embryonic lungs. This first observation of bronchoalveolar cancer arising from a major bronchus indicates that the carcinogen-induced neoplastic progression in bronchial epithelium may lead to type II cell differentiation and type II cell tumor development. The preservation of cell properties in serial nude mouse transplants suggests that it is a stable type II cell population.
