Lindusková M, Vykydal M
Výzkumný ústav chorob revmatických, Praha.
Cas Lek Cesk. 1990 Nov 30;129(48):1524-5.
The authors pay attention to benziodarone, a representative of the category of benzofurans. They test its effect on the uric acid serum level in normouraemic subjects as well as in hyperuricaemic syndrome and gouty arthritis. The hypouricaemic action of benziodarone (Amplivex-Labaz) is prompt. The maximum drop of uricaemia after Amplivex administration (2 tablets/day) occurs during the first three days. The uric acid level declines by as much as 80% of the baseline value. For long-term treatment 1 tablet per day is sufficient, in some instances even 1 tablet twice a week. The tolerance of the preparation is satisfactory. The authors deal also with the mechanism of action of benziodarone. Amplivex is not only a uricostatic but also a uricosuric agent.
作者关注苯碘达隆，它是苯并呋喃类的代表药物。他们测试了其对尿酸正常受试者以及高尿酸血症综合征和痛风性关节炎患者血清尿酸水平的影响。苯碘达隆（安普利维 - 拉巴兹）的降尿酸作用迅速。服用安普利维（每日2片）后，血尿酸在头三天内出现最大降幅。尿酸水平下降多达基线值的80%。长期治疗时，每日1片就足够，在某些情况下甚至每周两片。该制剂的耐受性良好。作者还探讨了苯碘达隆的作用机制。安普利维不仅是一种尿酸生成抑制剂，也是一种促尿酸排泄剂。
