Grindel S I, Wiederkehr J C, Pollak R
Department of Surgery, University of Illinois College of Medicine, Chicago 60680.
Curr Surg. 1990 Sep-Oct;47(5):321-6.
We designed a study to determine whether the mode of presentation of major histocompatibility antigens is important for the ability of donor-specific blood transfusions to prolong organ allograft survival. Donor BN rat whole blood, isolated RBC, RBC ghosts, RBC membrane fragments, or whole blood lysates were administered to Lewis rat recipients 7 days before heterotopic allotransplantation of BN hearts. Only allogeneic whole blood or RBC significantly prolonged cardiac allograft survival in this histoincompatible donor-recipient pair. Whole blood lysates or RBC ghosts and membrane fragments transfused pretransplant did not prolong cardiac allograft survival when compared with syngeneic, transfused control rats. These results suggest that the immunosuppressive effects of donor-specific pretransplant blood transfusion may depend on a three-dimensional spatial relation between cells bearing donor major histocompatibility antigens and recipient responder cells responsible for the transfusion effect.
我们设计了一项研究，以确定主要组织相容性抗原的呈现方式对于供体特异性输血延长器官同种异体移植存活时间的能力是否重要。在将BN心脏异位同种异体移植给Lewis大鼠受体前7天，给受体注射供体BN大鼠的全血、分离的红细胞、红细胞血影、红细胞膜片段或全血裂解物。在这个组织不相容的供体-受体对中，只有同种异体全血或红细胞能显著延长心脏同种异体移植的存活时间。与同基因输血对照大鼠相比，移植前输注全血裂解物或红细胞血影及膜片段并不能延长心脏同种异体移植的存活时间。这些结果表明，移植前供体特异性输血的免疫抑制作用可能取决于携带供体主要组织相容性抗原的细胞与负责输血效应的受体反应细胞之间的三维空间关系。
