Liu Hong-Xiao, Yin Hai-Bo, Wang Hai-Nan
Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Zhongguo Gu Shang. 2012 Feb;25(2):175-8.
Osteoarthritis is a common joint disease, which seriously affects the patient's health and quality of life. It results in substantial social and economic costs. Etiology and pathogenesis of OA is still not completely clear, but people paid more attention on Cytokines, especially IL-1, which is considered as core factor in the development of OA. In recent years, many clinical trials considered IL-1 as a target treatment for OA. It provided a new treatment method. This article is to overview the mechanism of IL-1 in OA cartilage damage.
骨关节炎是一种常见的关节疾病，严重影响患者的健康和生活质量。它会导致巨大的社会和经济成本。骨关节炎的病因和发病机制仍不完全清楚，但人们越来越关注细胞因子，尤其是白细胞介素-1，它被认为是骨关节炎发展的核心因素。近年来，许多临床试验将白细胞介素-1作为骨关节炎的靶向治疗药物。这提供了一种新的治疗方法。本文旨在概述白细胞介素-1在骨关节炎软骨损伤中的作用机制。
