LOX 出局，组蛋白：一种新的酶正在咬你的尾巴。

LOX out, histones: a new enzyme is nipping at your tails.

机构信息

Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

出版信息

Mol Cell. 2012 May 11;46(3):243-4. doi: 10.1016/j.molcel.2012.04.023.

DOI:10.1016/j.molcel.2012.04.023

PMID:22578539

Abstract

In the current issue of Molecular Cell, Herranz et al. (2012) demonstrate that LOXL2 deaminates trimethylated histone 3 lysine 4 (H3K4me3), which uncovers a new chromatin modification and a new enzymatic mechanism with the potential to regulate additional lysine residues.

摘要

在本期的《分子细胞》中，Herranz 等人（2012 年）证明 LOXL2 可以使组蛋白 3 赖氨酸 4 三甲基化（H3K4me3）脱氨基，这揭示了一种新的染色质修饰和一种具有潜在能力调节其他赖氨酸残基的新酶促机制。