National Research Laboratory of Vascular Biology and Stem Cells, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Trends Immunol. 2012 Jul;33(7):350-6. doi: 10.1016/j.it.2012.03.006. Epub 2012 May 12.
Lymphatic vessels (LVs) are highly dynamic structures that intimately interact with their surrounding microenvironment. They have a profound influence on the immune system and therefore can manipulate inflammatory processes. Inflammation is a major cause of adulthood lymphangiogenesis and LV remodeling. In turn, LVs can reciprocally manipulate inflammatory processes. For instance, LV growth and/or activation regulate antigen presentation and inflammatory cell recruitment to lymph nodes (LNs), and therefore critically affect adaptive immunity. The vascular endothelial growth factor (VEGF)-C-VEGF receptor-3 and VEGF-A-VEGF receptor-2 signaling pathways are particularly important in inflammatory lymphangiogenesis. LVs contribute to the pathophysiology of various inflammatory conditions. Knowledge of lymphatic biology can be applied to manipulate inflammatory disorders and divert immune responses. This review summarizes basic concepts of inflammation-relevant lymphatic biology, and describes recent progress and practical implications.
淋巴管 (LVs) 是高度动态的结构，与周围的微环境密切相互作用。它们对免疫系统有深远的影响，因此可以操纵炎症过程。炎症是成人淋巴管生成和 LV 重塑的主要原因。反过来，LVs 也可以相互影响炎症过程。例如，LV 的生长和/或激活调节抗原呈递和炎症细胞向淋巴结 (LNs) 的募集，因此对适应性免疫至关重要。血管内皮生长因子 (VEGF)-C-VEGF 受体-3 和 VEGF-A-VEGF 受体-2 信号通路在炎症性淋巴管生成中尤为重要。LVs 参与各种炎症状态的病理生理学。淋巴管生物学知识可用于操纵炎症性疾病并改变免疫反应。这篇综述总结了与炎症相关的淋巴管生物学的基本概念，并描述了最新进展和实际意义。
