Pharmacy Department, College of Medical Rehabilitation Sciences, Taibah University, Madinah Munawara, Saudi Arabia.
Int J Biol Macromol. 2012 Jul-Aug;51(1-2):7-17. doi: 10.1016/j.ijbiomac.2012.05.002. Epub 2012 May 8.
In continuation of our previous work, a novel series of polycyclic derivatives were synthesized and their anti-inflammatory, analgesic and antimicrobial activities were evaluated. Initially the acute toxicity of the compounds was assayed via the determination of their LD(50). Some of the newly compounds exhibited better biological and pharmacological activities than the reference controls with low toxicity (LD(50)). The structure of the new compounds has been established on the bases of chemical and spectroscopic evidences. The detailed synthesis, spectroscopic data, LD(50) and pharmacological activities of the synthesized compounds were reported.
延续我们之前的工作，我们合成了一系列新型的多环衍生物，并评估了它们的抗炎、镇痛和抗菌活性。首先，通过测定化合物的 LD(50)来评估其急性毒性。一些新化合物的生物和药理活性优于毒性较低的参比对照物（LD(50)）。新化合物的结构是基于化学和光谱证据确定的。详细的合成、光谱数据、LD(50)和合成化合物的药理活性都有报道。
