Pharmazentrum Frankfurt/ZAFES, Institut für Allgemeine Pharmakologie und Toxikologie, Klinikum der Goethe-Universität Frankfurt am Main, Frankfurt am Main, Germany.
Cell Cycle. 2012 Jun 1;11(11):2084-91. doi: 10.4161/cc.20316.
Inflammation is not only a defensive mechanism against microbial invasion, but also frequently represents a critical response to tissue injury under sterile conditions. It is now well established that tissue injury leads to the release of endogenous molecules of intra- and extracellular origin acting as damage-associated molecular patterns (DAMPs). The small leucine-rich proteoglycans (SLRPs) can act as powerful DAMPs following their proteolytical release from the extracellular matrix. Recent investigations of SLRP signaling networks revealed new levels of complexity, showing that SLRPs can cluster different types of receptors and orchestrate a host of downstream signaling events. This review will summarize the evidence for the multifunctional proinflammatory signaling properties of the two archetypal SLRPs, biglycan and decorin. These secreted proteoglycans link the innate to the adaptive immune response and operate in a broad biological context, encompassing microbial defense, tumor growth and autoimmunity.
炎症不仅是一种针对微生物入侵的防御机制，也是无菌条件下组织损伤的一种常见的关键反应。现在已经明确，组织损伤会导致内源性和细胞外源性的内源性分子的释放，这些分子作为损伤相关分子模式（DAMPs）起作用。小富含亮氨酸的蛋白聚糖（SLRPs）在从细胞外基质中进行蛋白水解释放后，可作为强大的 DAMPs 发挥作用。最近对 SLRP 信号网络的研究揭示了新的复杂性水平，表明 SLRPs 可以聚集不同类型的受体，并协调一系列下游信号事件。这篇综述将总结两个典型的 SLRPs（biglycan 和 decorin）具有多功能促炎信号特性的证据。这些分泌型蛋白聚糖将先天免疫与适应性免疫反应联系起来，并在广泛的生物学背景下发挥作用，包括微生物防御、肿瘤生长和自身免疫。
