Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología-Universidad Nacional Autónoma de México, Cuernavaca, México.
Cell Tissue Res. 2012 Sep;349(3):749-64. doi: 10.1007/s00441-012-1397-5. Epub 2012 May 15.
Spermatozoa must translate information from their environment and the egg to achieve fertilization in sexually reproducing animals. These tasks require decoding a variety of signals in the form of intracellular Ca(2+) changes. As TRP channels constitute a large family of versatile multi-signal transducers, they are interesting subjects in which to explore their possible participation in sperm function. Here, we review the evidence for their presence and involvement in sperm motility, maturation, and the acrosome reaction, an exocytotic process required for sperm-egg fusion. Since store-operated Ca(2+) entry (SOCE) has been proposed to play an important role in these three functions, the main proteins responsible for this transport (STIM and ORAI) and their interaction with TRPs are also discussed. Improving our tools to solve infertility, improve animal breeding, and preserve biodiversity requires a better understanding of how Ca(2+) is regulated in spermatozoa.
精子必须将环境和卵子中的信息翻译成在有性繁殖的动物中实现受精。这些任务需要解码各种形式的细胞内 Ca(2+)变化的信号。由于 TRP 通道构成了多功能多信号转导器的大家族，因此它们是探索其在精子功能中可能参与的有趣对象。在这里，我们回顾了它们在精子运动、成熟和顶体反应中的存在和参与的证据，顶体反应是精子-卵子融合所需的胞吐过程。由于已经提出储存操作的 Ca(2+)内流（SOCE）在这三个功能中发挥重要作用，因此还讨论了负责这种运输的主要蛋白质（STIM 和 ORAI）及其与 TRP 的相互作用。提高我们解决不孕、改善动物繁殖和保护生物多样性的工具需要更好地了解 Ca(2+)如何在精子中调节。
