TTT 三联体中的面选择性胸腺嘧啶-胸腺嘧啶光二聚化。
Facially-selective thymine-thymine photodimerization in TTT triads.
机构信息
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.
出版信息
Photochem Photobiol Sci. 2012 Jun;11(6):889-92. doi: 10.1039/c2pp25089f. Epub 2012 May 11.
PMID:22580641
Abstract
Irradiation of alkane-linked DNA hairpins possessing TTT steps with flanking purine bases yields products identified as the cis-syn (2 + 2) dimers formed between the central thymine and its 3'- and 5'-neighbors. Selective formation of the 3'-dimer is attributed to ground state conformational effects and electron transfer quenching by purine bases.
摘要
用侧翼嘌呤碱基照射具有 TTT 步的烷链连接 DNA 发夹，得到的产物被鉴定为在中央胸腺嘧啶与其 3'和 5'邻位之间形成的顺式-反式（2 + 2）二聚体。3'-二聚体的选择性形成归因于基态构象效应和嘌呤碱基的电子转移猝灭。
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