Buge A, Escourolle R, Rancurel G, Gray F, Pertuiset B F
Sem Hop. 1979;55(21-22):1051-5.
Three years following an irradiation by the Betatron's electron beam of an epithelioma in left parieto occipital area of the scalp in a female patient aged 77, early suffering from high blood pressure, a fatal pseudo-tumoral brain necrosis occurs presenting as a rapidly increasing from of Wernicke's aphasia. The necropsy shows intense radionecrosis lesions of the brain and the bone, free of any parenchymatous malignant proliferation note-worthy for the striking density of microvascular changes as previously described in radiation therapy. The case observed some years ago, allows to definite again the limits doses of the extracranial irradiations now estimated at 1760 rets. That is the "Nominal Standard Dose" (NSD) measured by rets and taking into account the number of seances (N) and the duration of irradiation (T) which would be to take the place of "the total dose" (D) (rads). These dosimetric criteria themselves must be adjusted to the age and the vascular features of each patient.
一名77岁女性患者,早年患有高血压,其头皮左顶枕区的上皮瘤接受了电子感应加速器电子束照射。三年后,发生了致命的假性肿瘤性脑坏死,表现为韦尼克失语症迅速加重。尸检显示脑和骨有严重的放射性坏死病变,无任何实质性恶性增殖,但微血管变化的显著密度值得注意,如先前在放射治疗中所描述的那样。几年前观察到的这个病例,再次确定了目前估计为1760雷姆的颅外照射极限剂量。这就是以雷姆测量的“标称标准剂量”(NSD),并考虑到疗程数(N)和照射持续时间(T),它将取代“总剂量”(D)(拉德)。这些剂量测定标准本身必须根据每个患者的年龄和血管特征进行调整。