The Home Peritoneal Dialysis Unit, Toronto General Hospital, University Health Network and University of Toronto, 200 Elizabeth Street, 8N-840, Toronto, ON, M5G 2C4, Canada.
Int Urol Nephrol. 2012 Dec;44(6):1861-9. doi: 10.1007/s11255-012-0180-6. Epub 2012 May 12.
The optimal target for glycated hemoglobin (HbA1c) has not been well defined in peritoneal dialysis (PD) patients with diabetes mellitus.
The objective of our study was to examine the predictive value of predialysis and time-averaged follow-up HbA1c values on technique and patient survival in diabetic PD patients treated in the Toronto General Hospital Home Peritoneal Dialysis Unit, between January 1, 2003 and December 31, 2008 with a median follow-up period of 30±23 months.
Ninety-one patients (mean age 64±13 years-old) were included in this retrospective study. Patients were followed between 3 and 91 months (mean duration 30±23 months). During this period, 40 patients died. We found no statistically significant correlation between baseline predialysis HbA1c values and technique and patient survival. Time-averaged follow-up HbA1c in increments<6.5%, 6.5-8%, and >8% showed no significant survival difference among groups.
There was no significant correlation of baseline and time-averaged follow-up HbA1c values with patient and PD technique survival.
糖化血红蛋白（HbA1c）的最佳目标尚未在患有糖尿病的腹膜透析（PD）患者中得到很好的定义。
我们的研究目的是检验在多伦多综合医院家庭腹膜透析中心接受治疗的糖尿病 PD 患者中，透析前和平均随访 HbA1c 值对技术和患者生存率的预测价值，这些患者在 2003 年 1 月 1 日至 2008 年 12 月 31 日期间接受治疗，中位随访时间为 30±23 个月。
这项回顾性研究共纳入 91 例（平均年龄 64±13 岁）患者。患者的随访时间为 3 至 91 个月（平均 30±23 个月）。在此期间，有 40 例患者死亡。我们发现透析前 HbA1c 值与技术和患者生存率之间没有统计学上的显著相关性。HbA1c 平均值在逐渐增加的 6.5%、6.5-8%和>8%之间，各组之间的生存率没有显著差异。
基线和平均随访 HbA1c 值与患者和 PD 技术生存率之间没有显著相关性。
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