PTK7 作为一种新型标志物，可预测胃癌患者的预后良好。

PTK7 as a novel marker for favorable gastric cancer patient survival.

机构信息

Department of Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.

出版信息

J Surg Oncol. 2012 Dec;106(7):880-6. doi: 10.1002/jso.23154. Epub 2012 May 14.

DOI:10.1002/jso.23154

PMID:22585737

Abstract

BACKGROUND AND OBJECTIVES

Protein tyrosine kinase 7 (PTK7) plays important functions in several cancer types but its expression in gastric cancer remains unknown. This study was designed to investigate PTK7 expression in gastric cancer.

METHODS

PTK7 expression was assessed by immunohistochemistry in 201 gastric cancer patients. The relationship between PTK7 expression and clinicopathological features and patients prognosis were statistically analyzed.

RESULTS

PTK7 expression was detected in 56.72% (114 of 201) of gastric cancer patients. The immunostaining was predominantly localized in the cytoplasm. The statistical analyses showed that PTK7 expression was more frequently detected in patients with well-differentiated tumors (P = 0.001). Furthermore, PTK7 expression was significantly related to the favorable overall survival (OS; P = 0.012) and disease-free survival (DFS; P = 0.009). Multivariate Cox regression analyses revealed that PTK7 expression was an independent prognostic factor for both favorable OS (P = 0.028) and DFS (P = 0.012).

CONCLUSION

Our findings demonstrate that PTK7 can serve as a novel prognostic biomarker for gastric cancer patients.

摘要

背景与目的

蛋白酪氨酸激酶 7（PTK7）在多种癌症类型中发挥着重要作用，但在胃癌中的表达情况尚不清楚。本研究旨在探讨 PTK7 在胃癌中的表达情况。

方法

采用免疫组织化学法检测 201 例胃癌患者中 PTK7 的表达情况。对 PTK7 表达与临床病理特征及患者预后的关系进行统计学分析。

结果

在 201 例胃癌患者中，检测到 56.72%（114/201）的患者存在 PTK7 表达。免疫染色主要定位于细胞质。统计分析表明，PTK7 表达在分化较好的肿瘤患者中更为常见（P=0.001）。此外，PTK7 表达与患者的总生存（OS；P=0.012）和无病生存（DFS；P=0.009）显著相关。多因素 Cox 回归分析显示，PTK7 表达是 OS（P=0.028）和 DFS（P=0.012）的独立预后因素。