Hassan Yahaya, Awaisu Ahmed, Al-Meman Ahmad Abdulrahman, Aziz Noorizan Abd
Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Malays J Med Sci. 2008 Apr;15(2):3-13.
Our objectives were to discuss a general overview on the description and recognition of heparin-induced thrombocytopenia (HIT) and present a critical review of the traditional and most recent advances in its pharmacotherapy. Computerized searches were done on MEDLINE and Iowa Drug Information Service (IDIS) databases from June 2001 until June 2007 and from May 2005 until May 2007, respectively. Search terms used included 'heparin-induced thrombocytopenia', 'heparin-associated thrombocytopenia', therapeutics, HIT, HAT. We largely selected publications within the timeframe above, but did not exclude commonly referenced and highly regarded older publications. The commonly referenced published articles were obtained through manual searches derived from bibliographic citations and retrievals from the authors' personal files. Pertinent literatures (89 key articles) that were thought to have substantially contributed new information to the therapeutics of HIT within the last 6 years were identified, reviewed and presented. The following limits were used for the MEDLINE and IDIS searches: 'human', drug therapy', 'review', 'meta-analysis', 'clinical trial', and case reports. The therapeutics of HIT is rapidly evolving and needs to consider an evidence - based approach. It is imperative that practitioners be aware of the associated risk and be up-to-date with the current advances in the management of this fatal clinical condition.
我们的目标是讨论肝素诱导的血小板减少症（HIT）的描述与识别的总体概况，并对其药物治疗方面的传统进展和最新进展进行批判性综述。分别在2001年6月至2007年6月以及2005年5月至2007年5月期间，对MEDLINE和爱荷华药物信息服务（IDIS）数据库进行了计算机检索。使用的检索词包括“肝素诱导的血小板减少症”、“肝素相关血小板减少症”、治疗学、HIT、HAT。我们主要选择上述时间范围内的出版物，但不排除经常被引用且广受认可的旧出版物。通过对文献引用进行人工检索以及从作者个人文件中获取相关文献，从而获得了经常被引用的已发表文章。我们识别、综述并呈现了在过去6年中被认为对HIT治疗有重大新贡献的相关文献（89篇关键文章）。MEDLINE和IDIS检索使用了以下限定条件：“人类”、“药物治疗”、“综述”、“荟萃分析”、“临床试验”以及病例报告。HIT的治疗方法正在迅速发展，需要考虑基于证据的方法。从业者必须意识到相关风险，并了解这种致命临床病症管理方面的当前进展。
