CYP2D6基因多态性对马来西亚精神分裂症患者症状学及副作用的影响。
Influence of CYP2D6 polymorphisms on symptomatology and side-effects of patients with schizophrenia in Malaysia.
作者信息
Zahari Zalina, Salleh Mohd Razali, Teh Lay Kek, Ismail Rusli
机构信息
Pharmacogenetics Research Group, Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia Health Campus & Department of Pharmacy, Hospital Universiti Sains Malaysia, Universiti Sains Malaysia Health Campus, Jln Raja Perempuan Zainab II, 16150 Kubang Kerian, Kelantan, Malaysia.
出版信息
Malays J Med Sci. 2009 Jul;16(3):12-20.
BACKGROUND
Our objective was to investigate the association of CYP2D6 polymorphisms with symptoms and side-effects of patients with schizophrenia.
METHODS
The subjects were 156 patients with schizophrenia undergoing antipsychotic treatment at a psychiatric clinic. Patients with co-morbid diagnoses of substance abuse or mental retardation were excluded from the study. Psychopathology was evaluated using the Positive and Negative Symptoms Scale (PANSS). Extrapyramidal side-effects and akathisia were assessed with the Simpson Angus Scale (SAS) and the Barnes Akathisia Rating Scale (BARS), respectively. DNA was extracted from blood and subjected to PCR-genotyping.
RESULTS
We found that CYP2D6 polymorphisms were significantly associated with a subtotal negative PANSS score. In addition, CYP2D6 is not related to side-effects of antipsychotic therapy, or SAS and BARS scores. The results suggest that CYP2D6 polymorphisms may have implications in treatment response.
CONCLUSIONS
Therefore, CYP2D6 may be a predictor for treatment outcomes of patients with schizophrenia. However, further investigation is required to confirm these findings in a larger sample.
背景
我们的目的是研究CYP2D6基因多态性与精神分裂症患者症状及副作用之间的关联。
方法
研究对象为156名在精神科诊所接受抗精神病药物治疗的精神分裂症患者。共病有药物滥用或智力发育迟缓诊断的患者被排除在研究之外。使用阳性和阴性症状量表（PANSS）评估精神病理学。分别使用辛普森·安格斯量表（SAS）和巴恩斯静坐不能评定量表（BARS）评估锥体外系副作用和静坐不能。从血液中提取DNA并进行PCR基因分型。
结果
我们发现CYP2D6基因多态性与PANSS总分阴性显著相关。此外，CYP2D6与抗精神病治疗的副作用或SAS和BARS评分无关。结果表明CYP2D6基因多态性可能对治疗反应有影响。
结论
因此，CYP2D6可能是精神分裂症患者治疗结果的一个预测指标。然而，需要进一步研究以在更大样本中证实这些发现。
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