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替佐硝唑吡啶单溶剂合物

Tizoxanide pyridine monosolvate.

作者信息

Zheng Huaqin, Deng Hui, Chen Yunyun, Li Ding

机构信息

School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1453-4. doi: 10.1107/S1600536812016133. Epub 2012 Apr 21.

DOI:10.1107/S1600536812016133
PMID:22590331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3344569/
Abstract

IN THE TITLE COMPOUND [SYSTEMATIC NAME: 2-hy-droxy-N-(5-nitro-1,3-thia-zol-2-yl)benzamide pyridine monosolvate], C(10)H(7)N(3)O(4)S·C(5)H(5)N, the dihedral angle between the pyridine and benzamide rings is 80.55 (7)°. An intamolecular O-H⋯N hydrogen bond occurs in the tizoxanide. In the crystal, the components are linked by an O-H⋯N hydrogen bond, forming a zigzag chain along the c axis. Aromatic π-π inter-actions between inversion-related pyridine rings [centroid-centroid distance = 3.803 (6) Å] are also observed.

摘要

在标题化合物[系统名称：2-羟基-N-(5-硝基-1,3-噻唑-2-基)苯甲酰胺吡啶单溶剂合物]，C(10)H(7)N(3)O(4)S·C(5)H(5)N中，吡啶环和苯甲酰胺环之间的二面角为80.55 (7)°。替唑尼特中存在分子内O-H⋯N氢键。在晶体中，各组分通过O-H⋯N氢键相连，沿c轴形成之字形链。还观察到与反演相关的吡啶环之间的芳香π-π相互作用[质心-质心距离 = 3.803 (6) Å]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/283e248bd91b/e-68-o1453-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/d1ca84e3c74b/e-68-o1453-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/e0b950d23a97/e-68-o1453-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/283e248bd91b/e-68-o1453-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/d1ca84e3c74b/e-68-o1453-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/e0b950d23a97/e-68-o1453-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab41/3344569/283e248bd91b/e-68-o1453-fig3.jpg

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本文引用的文献

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2
Thiazolides as novel antiviral agents. 2. Inhibition of hepatitis C virus replication.噻唑烷类化合物作为新型抗病毒药物。2. 抑制丙型肝炎病毒复制。
J Med Chem. 2011 Dec 22;54(24):8670-80. doi: 10.1021/jm201264t. Epub 2011 Nov 21.
3
Thiazolides as novel antiviral agents. 1. Inhibition of hepatitis B virus replication.噻唑烷类化合物作为新型抗病毒药物。1. 抑制乙型肝炎病毒复制。
J Med Chem. 2011 Jun 23;54(12):4119-32. doi: 10.1021/jm200153p. Epub 2011 May 23.
4
Synthesis of benzologues of Nitazoxanide and Tizoxanide: a comparative study of their in vitro broad-spectrum antiprotozoal activity.硝唑尼特和替硝唑苯并呋喃类似物的合成：体外广谱抗原生动物活性比较研究。
Bioorg Med Chem Lett. 2011 May 15;21(10):3168-71. doi: 10.1016/j.bmcl.2011.02.100. Epub 2011 Feb 26.
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In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide.犬甲型流感病毒（H3N8）对硝唑尼特和替唑尼特的体外敏感性
Vet Med Int. 2010 Aug 12;2010:891010. doi: 10.4061/2010/891010.
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The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro.
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Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes.马来布鲁线虫：硝唑尼特和替唑尼特对丝虫线虫成虫及微丝蚴的作用
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