替佐硝唑吡啶单溶剂合物
Tizoxanide pyridine monosolvate.
作者信息
Zheng Huaqin, Deng Hui, Chen Yunyun, Li Ding
机构信息
School of Pharmaceutical Science, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China.
出版信息
Acta Crystallogr Sect E Struct Rep Online. 2012 May 1;68(Pt 5):o1453-4. doi: 10.1107/S1600536812016133. Epub 2012 Apr 21.
IN THE TITLE COMPOUND [SYSTEMATIC NAME: 2-hy-droxy-N-(5-nitro-1,3-thia-zol-2-yl)benzamide pyridine monosolvate], C(10)H(7)N(3)O(4)S·C(5)H(5)N, the dihedral angle between the pyridine and benzamide rings is 80.55 (7)°. An intamolecular O-H⋯N hydrogen bond occurs in the tizoxanide. In the crystal, the components are linked by an O-H⋯N hydrogen bond, forming a zigzag chain along the c axis. Aromatic π-π inter-actions between inversion-related pyridine rings [centroid-centroid distance = 3.803 (6) Å] are also observed.
在标题化合物[系统名称：2-羟基-N-(5-硝基-1,3-噻唑-2-基)苯甲酰胺吡啶单溶剂合物]，C(10)H(7)N(3)O(4)S·C(5)H(5)N中，吡啶环和苯甲酰胺环之间的二面角为80.55 (7)°。替唑尼特中存在分子内O-H⋯N氢键。在晶体中，各组分通过O-H⋯N氢键相连，沿c轴形成之字形链。还观察到与反演相关的吡啶环之间的芳香π-π相互作用[质心-质心距离 = 3.803 (6) Å]。
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