Uppsala University, Department of Neuroscience, Uppsala, Sweden.
Neurobiol Aging. 2013 Jan;34(1):83-90. doi: 10.1016/j.neurobiolaging.2012.04.013. Epub 2012 May 15.
In the present cross-sectional study, we examined physical activity (PA) and its possible association with cognitive skills and brain structure in 331 cognitively healthy elderly. Based on the number of self-reported light and hard activities for at least 30 minutes per week, participants were assigned to 4 groups representing different levels of PA. The cognitive skills were assessed by the Mini Mental State Examination score, a verbal fluency task, and the Trail-making test as a measure of visuospatial orientation ability. Participants also underwent a magnetic resonance imaging of the brain. Multiple regression analysis revealed that greater PA was associated with a shorter time to complete the Trail-making test, and higher levels of verbal fluency. Further, the level of self-reported PA was positively correlated with brain volume, white matter, as well as a parietal lobe gray matter volume, situated bilaterally at the precuneus. These present cross-sectional results indicate that PA is a lifestyle factor that is linked to brain structure and function in late life.
在这项横断面研究中，我们研究了 331 名认知健康的老年人的体力活动（PA）及其与认知技能和大脑结构的可能关联。根据每周至少进行 30 分钟的轻体力活动和重体力活动的次数，参与者被分为 4 组，代表不同水平的 PA。认知技能通过简易精神状态检查评分、词语流畅性任务和 Trail-making 测试进行评估，作为视空间定向能力的衡量标准。参与者还接受了大脑的磁共振成像检查。多元回归分析显示，更高水平的 PA 与完成 Trail-making 测试的时间更短以及词语流畅性水平更高有关。此外，自我报告的 PA 水平与大脑体积、白质以及双侧顶叶后扣带回的灰质体积呈正相关。这些横断面研究结果表明，PA 是一种生活方式因素，与晚年的大脑结构和功能有关。
