Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Department of Neuroscience, University of Rochester, Rochester, NY, USA.
BMC Geriatr. 2024 Oct 11;24(1):816. doi: 10.1186/s12877-023-04594-7.
The worldwide number of adults aged 60 years and older is expected to double from 1 billion in 2019 to 2.1 billion by 2050. As the population lives longer, the rising incidence of chronic diseases, cognitive disorders, and behavioral health issues threaten older adults' health span. Exercising, getting sufficient sleep, and staying mentally and socially active can improve quality of life, increase independence, and potentially lower the risk for Alzheimer's disease or other dementias. Nonpharmacological approaches might help promote such behaviors. Indoor lighting may impact sleep quality, physical activity, and cognitive function. Dynamically changing indoor lighting brightness and color throughout the day has positive effects on sleep, cognitive function, and physical activity of its occupants. The aim of this study is to investigate how different indoor lighting conditions affect such health measures to promote healthier aging.
This protocol is a randomized, cross-over, single-site trial followed by an exploratory third intervention. Up to 70 older adults in independent living residences at a senior living facility will be recruited. During this 16-week study, participants will experience three lighting conditions. Two cohorts will first experience a static and a dynamic lighting condition in a cluster-randomized cross-over design. The static condition lighting will have fixed brightness and color to match lighting typically provided in the facility. For the dynamic condition, brightness and color will change throughout the day with increased brightness in the morning. After the cross-over, both cohorts will experience another dynamic lighting condition with increased morning brightness to determine if there is a saturation effect between light exposure and health-related measures. Light intake, sleep quality, and physical activity will be measured using wearable devices. Sleep, cognitive function, mood, and social engagement will be assessed using surveys and cognitive assessments.
We hypothesize participants will have better sleep quality and greater physical activity during the dynamic lighting compared to the static lighting condition. Additionally, we hypothesize there is a maximal threshold at which health-outcomes improve based on light exposure. Study findings may identify optimal indoor lighting solutions to promote healthy aging for older adults.
ClinicalTrials.gov Identifier: NCT05978934.
预计到 2050 年，全球 60 岁及以上成年人的数量将从 2019 年的 10 亿增加到 21 亿。随着人口寿命的延长，慢性疾病、认知障碍和行为健康问题的发病率上升，威胁着老年人的健康寿命。锻炼、充足的睡眠以及保持身心活跃可以提高生活质量、增加独立性，并降低患阿尔茨海默病或其他痴呆症的风险。非药物干预措施可能有助于促进这些行为。室内照明可能会影响睡眠质量、身体活动和认知功能。在一天中动态改变室内照明的亮度和颜色对其居住者的睡眠、认知功能和身体活动有积极影响。本研究的目的是调查不同的室内照明条件如何影响这些健康措施，以促进更健康的老龄化。
本方案是一项随机、交叉、单站点试验，随后进行探索性的第三次干预。将在一家老年生活设施的独立居住住宅中招募多达 70 名老年人。在这项为期 16 周的研究中，参与者将体验三种照明条件。两个队列将首先在集群随机交叉设计中体验静态和动态照明条件。静态照明条件的亮度和颜色将固定，以匹配设施中提供的照明。对于动态条件，亮度和颜色将在一天中变化，早晨的亮度会增加。交叉后，两个队列都将体验另一种具有更高早晨亮度的动态照明条件，以确定在光暴露与健康相关测量之间是否存在饱和效应。使用可穿戴设备测量光摄入量、睡眠质量和身体活动。使用调查和认知评估评估睡眠、认知功能、情绪和社会参与度。
我们假设与静态照明条件相比，参与者在动态照明条件下的睡眠质量更好，身体活动更多。此外，我们假设基于光暴露，健康结果的改善存在最大阈值。研究结果可能会确定最佳的室内照明解决方案，以促进老年人的健康老龄化。
ClinicalTrials.gov 标识符：NCT05978934。
