Department of Clinical Psychiatry, Beijing Anding Hospital, Capital Medical University, Beijing 100088, PR China.
Behav Brain Res. 2012 Jul 15;233(1):237-43. doi: 10.1016/j.bbr.2012.05.007. Epub 2012 May 15.
Alzheimer's disease (AD) is a neurodegenerative disorder associated with cognitive deterioration and neuropsychiatric symptoms. Sensorimotor gating deficit has been identified in neuropsychiatric diseases. The aim of the present study was to evaluate the possible sensorimotor gating deficit and its correlation to memory impairment and cerebral β-amyloid (Aβ) plaque deposits in an amyloid precursor protein (APP)/presenilin-1 (PS1) double transgenic mouse model of AD. The sensorimotor gating in 3-, 7- and-22-month-old non-transgenic and transgenic mice was evaluated in a prepulse inhibition (PPI) task. Results revealed that the PPI was lower in the 7- and 22-month-old transgenic mice compared with the age-matched control, while the response to startle pulse-alone in the transgenic and non-transgenic mice was comparable. Congo red staining showed that Aβ neuropathology of transgenic mice aggravated with age, and the 3-month-old transgenic mice started to have minimum brain Aβ plaques, corresponding to the early stage of AD phenotype. Furthermore, memory impairment in the 7-month-old transgenic mice was detected in a water maze test. These results suggest that the sensorimotor gating is impaired with the progressing of AD phenotype, and its deficit may be correlated to cerebral Aβ neuropathology and memory impairment in the APP/PS1 transgenic mouse model of AD.
阿尔茨海默病（AD）是一种与认知功能恶化和神经精神症状相关的神经退行性疾病。感觉运动门控缺陷已在神经精神疾病中得到鉴定。本研究旨在评估 APP/PS1 双转基因 AD 小鼠模型中可能存在的感觉运动门控缺陷及其与记忆障碍和脑β-淀粉样蛋白（Aβ）斑块沉积的相关性。在预脉冲抑制（PPI）任务中评估了 3、7 和 22 月龄非转基因和转基因小鼠的感觉运动门控。结果表明，与年龄匹配的对照组相比，7 月龄和 22 月龄的转基因小鼠的 PPI 较低，而转基因和非转基因小鼠对起始脉冲的反应相似。刚果红染色显示，转基因小鼠的 Aβ神经病理学随年龄加重，3 月龄的转基因小鼠开始出现最少的脑 Aβ斑块，对应 AD 表型的早期阶段。此外，在水迷宫测试中检测到 7 月龄转基因小鼠的记忆障碍。这些结果表明，感觉运动门控随着 AD 表型的进展而受损，其缺陷可能与脑 Aβ 神经病理学和 AD 的 APP/PS1 转基因小鼠模型中的记忆障碍相关。
