Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
Neurosci Lett. 2012 Jun 27;520(1):43-6. doi: 10.1016/j.neulet.2012.05.027. Epub 2012 May 15.
It has been demonstrated that galanin plays important roles in the modulation of nociceptive information in rats. The present study is performed to investigate the regulating role of galanin in nociception in the nucleus accumbens (NAc) of rats. Intra-NAc administration of galanin induces dose-dependent increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. Furthermore, the galanin-induced antinociceptive effects are blocked by following intra-NAc injection of the galanin receptor antagonist galantide. The results demonstrate that galanin induces antinociceptive effects in the NAc of rats, and galanin receptors are involved in the galanin-induced antinociception effects.
已经证明甘丙肽在调节大鼠伤害性信息方面发挥着重要作用。本研究旨在探讨甘丙肽在大鼠伏隔核（NAc）中对伤害性感受的调节作用。NAc 内给予甘丙肽可引起大鼠足底回缩潜伏期（HWL）对有害热和机械刺激的剂量依赖性增加。此外，甘丙肽诱导的抗伤害效应可被 NAc 内注射甘丙肽受体拮抗剂 galantide 阻断。结果表明，甘丙肽在大鼠的 NAc 中诱导出抗伤害效应，而甘丙肽受体参与了甘丙肽诱导的抗伤害效应。
