Tjandra J J, Smith J A, Collins J P, Russell I S, McKenzie I F
Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
Singapore Med J. 1990 Oct;31(5):502-5.
There is an increased incidence of colonic carcinoma in patients with breast carcinoma but colonic involvement secondary to breast carcinoma can also occur. The differentiation of the organ or origin (breast vs colon) of the abdominal tumour can be difficult and may benefit from the use of immunohistochemical staining with monoclonal antibodies that react preferentially with colon cancer (JGT) and breast cancer (3E1.2, BC2,BC3). Measurement of Mammary Serum Antigen (MSA) level as detected by the anti-breast monoclonal antibody (3E1.2) was also useful in the classification of tumours of uncertain origin.
乳腺癌患者患结肠癌的几率增加，但也可能出现继发于乳腺癌的结肠受累情况。区分腹部肿瘤的器官或起源（乳腺与结肠）可能很困难，使用优先与结肠癌（JGT）和乳腺癌（3E1.2、BC2、BC3）反应的单克隆抗体进行免疫组织化学染色可能会有所帮助。用抗乳腺单克隆抗体（3E1.2）检测的乳腺血清抗原（MSA）水平测量对于不确定起源肿瘤的分类也很有用。
