England D M, Solie B, Winkelmann R K
Arch Pathol Lab Med. 1979 Oct;103(11):586-90.
Isoantigens A, B, H(O) in biopsy specimens of 26 normal skin and in 35 adnexal tumors were studied by the red cell adherence (RCA) test of Davidsohn. Isoantigens were detected in the stratum corneum, stratum granulosum, stratum spinosum, acrosyringium, keratogenous zone of hair follicle, eccrine duct, and eccrine gland. The apocrine gland and duct consistently had negative test results for isoantigens. Seventy percent of all tumors tested contained isoantigens and included syringoma, hidrocystoma, syringocystadenoma papilliferum, spiradenoma, eccrine poroma, dermal duct tumor, clear cell hidradenoma, and cylindroma. We interpreted the presence of isoantigens in adnexal tumors as being evidence of immunologic maturity with differentiation toward eccrine structures. The RCA test is a new, sensitive, immunologic technique that can complement enzyme histochemical stains and electron microscopy in the study of the histogenesis of adnexal skin tumors.
采用大卫索恩红细胞黏附（RCA）试验，对26例正常皮肤活检标本和35例附属器肿瘤进行了同种抗原A、B、H（O）的研究。在角质层、颗粒层、棘层、顶泌汗腺导管、毛囊的角质形成区、小汗腺导管和小汗腺中检测到了同种抗原。大汗腺及其导管的同种抗原检测结果始终为阴性。所有检测的肿瘤中有70%含有同种抗原，包括汗管瘤、汗腺囊瘤、乳头状汗管囊腺瘤、螺旋腺瘤、小汗腺汗孔瘤、皮肤导管瘤、透明细胞汗腺瘤和圆柱瘤。我们将附属器肿瘤中同种抗原的存在解释为向小汗腺结构分化的免疫成熟证据。RCA试验是一种新型、敏感的免疫技术，在附属器皮肤肿瘤组织发生学研究中可补充酶组织化学染色和电子显微镜检查。
