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子宫上皮样平滑肌肉瘤

Epithelioid leiomyosarcoma of uterus.

作者信息

Setia Aparna, Kanotra Shalini, Aggarwal Ritika, Bhavthankar Dilip Prabhakarrao

机构信息

Obstetrics and Gynaecology Department, Pravara Institute of Medical Sciences, Ahmednagar, India.

出版信息

BMJ Case Rep. 2012 Apr 2;2012:bcr1120115144. doi: 10.1136/bcr.11.2011.5144.

Abstract

Fibroid most commonly presents in the reproductive age group and presence of fibroid with postmenopausal bleeding is a rare entity and all investigations and measures should be done to rule out leiomyosarcoma. A 45-year-old female had attained menopause 3 year back and developed postmenopausal bleeding since 2 months, with palpable mass, of 24 weeks size. Ultrasonography showed multiple whorled mass lesions, endometrium and myometrium could not be seen separately. Total abdominal hysterectomy with bilateral salpingoophorectomy was performed. Intraoperative findings showed 24 weeks uterine mass with size 17.5×15.5×11.5 cm and weight 1.9 kg with multiple, intramural fibroids. Cut section of removed specimen showed black and yellow necrotic and haemorrhagic areas with degenerative changes suggestive of malignancy. Histopathology reported epithelioid leiomyosarcoma.

摘要

子宫肌瘤最常见于育龄期女性,绝经后出血合并子宫肌瘤是一种罕见情况,应进行所有检查和采取所有措施以排除平滑肌肉瘤。一名45岁女性3年前已绝经,近2个月出现绝经后出血,可触及大小如孕24周的肿块。超声检查显示多个漩涡状肿块病变,无法分别看清子宫内膜和肌层。遂行全腹子宫切除术及双侧输卵管卵巢切除术。术中所见为一个大小为17.5×15.5×11.5 cm、重量为1.9 kg的孕24周子宫肿块,伴有多个壁间子宫肌瘤。切除标本的切面显示有黑色和黄色坏死及出血区域,伴有提示恶性的退行性改变。组织病理学报告为上皮样平滑肌肉瘤。

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本文引用的文献

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Optimal management of uterine leiomyosarcoma.子宫平滑肌肉瘤的最佳治疗方法。
Expert Rev Anticancer Ther. 2010 Feb;10(2):153-69. doi: 10.1586/era.09.187.
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Uterine sarcomas: a review.子宫肉瘤:综述
Gynecol Oncol. 2010 Jan;116(1):131-9. doi: 10.1016/j.ygyno.2009.09.023. Epub 2009 Oct 23.
6
Uterine sarcoma: twenty-seven years of experience.子宫肉瘤:二十七年的经验
Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1366-73. doi: 10.1016/s0360-3016(03)00750-8.
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Epithelioid leiomyosarcoma of the uterus.子宫上皮样平滑肌肉瘤
Cancer. 1986 Mar 15;57(6):1192-6. doi: 10.1002/1097-0142(19860315)57:6<1192::aid-cncr2820570621>3.0.co;2-b.

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