丙戊酸糖浆中的辅料可能导致腹泻：一例病例报告。

Excipients in valproic acid syrup may cause diarrhea: a case report.

作者信息

Veerman M W

机构信息

Department of Pharmacy Services, Shands Hospital, University of Florida, Gainesville 32610.

出版信息

DICP. 1990 Sep;24(9):832-3. doi: 10.1177/106002809002400907.

DOI:10.1177/106002809002400907

PMID:2260339

Abstract

A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients. Each 5 mL of valproic acid syrup contains sucrose 3 g, glycerin 0.75 g, and sorbitol 0.75 g, providing daily amounts of 36, 9, and 9 g of sucrose, glycerin, and sorbitol, respectively. The diarrhea resolved when the child was switched to another valproic acid product. Clinicians should be aware of potential problems that may occur from excipient ingredients in pharmaceutical products when evaluating adverse effects of medications.

摘要

一名正在服用丙戊酸糖浆以控制癫痫发作的5岁儿童出现了可能由辅料成分引起的腹泻。每5毫升丙戊酸糖浆含有3克蔗糖、0.75克甘油和0.75克山梨醇，分别提供每日36克、9克和9克的蔗糖、甘油和山梨醇。当该儿童改用另一种丙戊酸产品时，腹泻症状消失。临床医生在评估药物不良反应时，应注意药品辅料成分可能引发的潜在问题。