急性巨核细胞白血病的尸检诊断。免疫组织化学和组织血细胞计数的实用性。

Postmortem diagnosis of acute megakaryocytic leukemia. Usefulness of immunohistochemistry and tissue hemogram.

作者信息

Umezawa A, Yamada T, Ogawa Y, Kuramochi S, Watanabe Y

机构信息

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

出版信息

Acta Pathol Jpn. 1990 Sep;40(9):693-8. doi: 10.1111/j.1440-1827.1990.tb01618.x.

DOI:10.1111/j.1440-1827.1990.tb01618.x

PMID:2260477

Abstract

An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)-positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa-positive blasts and megakaryoblasts were deposited massively in lymph nodes. Immunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultrastructural platelet peroxidase in autopsy materials is difficult.

摘要

本文报告1例急性巨核细胞白血病（AMKL）尸检病例。骨髓细胞增生，三系均有增殖，尤其是巨核细胞。免疫组化检查显示骨髓中有许多血小板糖蛋白IIb/IIIa（GP IIb/IIIa）阳性的原始细胞。组织血细胞计数显示原始细胞比例为26.4%。GP IIb/IIIa阳性原始细胞和原始巨核细胞大量沉积于淋巴结。由于在尸检材料中难以鉴定超微结构的血小板过氧化物酶，因此尸检诊断AMKL需要通过石蜡切片进行GP IIb/IIIa免疫组化和组织血细胞计数。