Umezawa A, Yamada T, Ogawa Y, Kuramochi S, Watanabe Y
Department of Pathology, Keio University School of Medicine, Tokyo, Japan.
Acta Pathol Jpn. 1990 Sep;40(9):693-8. doi: 10.1111/j.1440-1827.1990.tb01618.x.
An autopsy case of acute megakaryocytic leukemia (AMKL) is presented. The bone marrow was hypercellular with proliferation of three lineages, especially megakaryocytes. Immunohistochemical examination revealed many platelet glycoprotein IIb/IIIa (GP IIb/IIIa)-positive blast cells in bone marrow. The proportion of the blasts was 26.4% by tissue hemogram. GP IIb/IIIa-positive blasts and megakaryoblasts were deposited massively in lymph nodes. Immunohistochemistry against GP IIb/IIIa and tissue hemograms by paraffin section are needed to diagnose AMKL by postmortem examination, since the identification of ultrastructural platelet peroxidase in autopsy materials is difficult.
本文报告1例急性巨核细胞白血病（AMKL）尸检病例。骨髓细胞增生，三系均有增殖，尤其是巨核细胞。免疫组化检查显示骨髓中有许多血小板糖蛋白IIb/IIIa（GP IIb/IIIa）阳性的原始细胞。组织血细胞计数显示原始细胞比例为26.4%。GP IIb/IIIa阳性原始细胞和原始巨核细胞大量沉积于淋巴结。由于在尸检材料中难以鉴定超微结构的血小板过氧化物酶，因此尸检诊断AMKL需要通过石蜡切片进行GP IIb/IIIa免疫组化和组织血细胞计数。
