McCrea Patrick H, Chang Michelle, Bailley Gregory, Molinari Michele
Surgery Department, Dalhousie University, Halifax, Canada.
BMJ Case Rep. 2012 Apr 28;2012:bcr0120125537. doi: 10.1136/bcr.01.2012.5537.
Carcinosarcoma and sarcomatoid carcinoma of the bladder after organ transplantation is higher in comparison to the general population but overall occurrence is still very uncommon. Due to the decreased immunitary response effects of antirejection drugs, these cancers have aggressive course and respond poorly to treatment. Bladder drained pancreatic transplants are associated with a number of urologic challenges that can delay the diagnosis and the treatment of malignancies of the genito-urinary system. The authors present a case of a rare sarcomatoid carcinoma of the bladder following bladder drained simultaneous kidney and pancreas transplant and discuss its pathogenesis and clinical management.
器官移植后膀胱发生癌肉瘤和肉瘤样癌的几率高于普通人群，但总体发生率仍然很低。由于抗排斥药物降低了免疫反应效应，这些癌症病程进展迅速，对治疗反应不佳。膀胱引流式胰腺移植会带来一些泌尿系统方面的挑战，可能会延误泌尿生殖系统恶性肿瘤的诊断和治疗。作者报告了一例膀胱引流式同期肾胰腺移植术后罕见的膀胱肉瘤样癌病例，并讨论了其发病机制和临床处理方法。
