Shi Jing, Yao Demao, Liu Wei, Wang Na, Lv Hongjun, He Nongyue, Shi Bingyin, Hou Peng, Ji Meiju
Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Department of Surgery, The First Affiliated Hospital of Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Int J Mol Sci. 2012;13(4):4714-4726. doi: 10.3390/ijms13044714. Epub 2012 Apr 13.
Gastric cancer is one of the most common malignancies worldwide. However, genetic alterations leading to this disease are largely unknown. Gene amplification is one of the most frequent genetic alterations, which is believed to play a major role in the development and progression of gastric cancer. In the present study, we identified three frequently amplified genes from 30 candidate genes using real-time quantitative PCR method, including ERBB4, C-MET and CD44, and further explored their association with clinicopathological characteristics and poor survival in a cohort of gastric cancers. Our data showed amplification of these genes was significantly associated with certain clinicopathological characteristics, particularly tumor differentiation and cancer-related death. More importantly, amplification of these genes was significantly related to worse survival, suggesting that these amplified genes may be significant predictors of poor prognosis and potential therapeutic targets in gastric cancer. Targeting these genes may thus provide new possibilities in the treatment of gastric cancer.
胃癌是全球最常见的恶性肿瘤之一。然而，导致这种疾病的基因改变在很大程度上尚不清楚。基因扩增是最常见的基因改变之一，被认为在胃癌的发生和发展中起主要作用。在本研究中，我们使用实时定量PCR方法从30个候选基因中鉴定出三个频繁扩增的基因，包括ERBB4、C-MET和CD44，并进一步探讨了它们与一组胃癌患者临床病理特征及不良生存的关系。我们的数据显示，这些基因的扩增与某些临床病理特征显著相关，尤其是肿瘤分化和癌症相关死亡。更重要的是，这些基因的扩增与较差的生存率显著相关，这表明这些扩增基因可能是胃癌预后不良的重要预测指标和潜在治疗靶点。因此，针对这些基因可能为胃癌治疗提供新的可能性。
