三例同胞兄妹患法洛四联症
Tetralogy of Fallot in three sibs.
作者信息
Pankau R, Siekmeyer W, Stoffregen R
机构信息
Department of Pediatrics, University Hospital of Kiel, West Germany.
出版信息
Am J Med Genet. 1990 Dec;37(4):532-3. doi: 10.1002/ajmg.1320370421.
PMID:2260602
Abstract
We report on three sibs (2 boys, one girl) with tetralogy of Fallot from non-consanguineous parents. The first child died during corrective surgery in 1972 from irreversible right ventricular failure. Corrective surgery was successful in the 2nd son and the daughter. The occurrence of tetralogy of Fallot in 3 sibs suggests a recessive gene.
摘要
我们报告了3名患有法洛四联症的同胞（2名男孩，1名女孩），其父母非近亲结婚。第一个孩子于1972年在矫正手术期间因不可逆的右心室衰竭死亡。矫正手术在第二个儿子和女儿身上取得成功。3名同胞均患法洛四联症提示存在隐性基因。
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