Paciuc-Beja Miguel, Retchkiman-Bret Myriam, Velasco-Barona Cecilio Francisco, Galicia-Alfaro Victor Hugo
Eye Clinic, Denver Health and Hospital Authority, Davis Pavillion, Colorado, 777 Bannock Street, Denver, CO 80204, USA.
Case Rep Ophthalmol Med. 2011;2011:594051. doi: 10.1155/2011/594051. Epub 2011 Dec 22.
We examined a 39-year-old female with severe headache and blurred vision. She was on topiramate, 50 mg once a day for one week because of migraine. Periorbital edema, chemosis, myopia, high intraocular pressures, and shallow anterior chambers were present at the initial examination. Iridocorneal angles were closed, ultrasound showed choroidal effusions. We stopped topiramate and started antiglaucoma treatment. After one week the intraocular pressure was 10 mm Hg in both eyes without treatment. A new ultrasound showed no choroidal effusions. Topiramate has been associated with acute secondary angle closure glaucoma as an idiosyncratic reaction to the drug. Physicians prescribing topiramate need to alert patients of this potential sight-threatening idiosyncratic reaction.
我们检查了一名39岁患有严重头痛和视力模糊的女性。她因偏头痛服用托吡酯，每天50毫克，服用了一周。初次检查时发现有眶周水肿、球结膜水肿、近视、高眼压和前房浅。虹膜角膜角关闭，超声显示脉络膜积液。我们停用了托吡酯并开始抗青光眼治疗。一周后，未经治疗双眼眼压均为10毫米汞柱。新的超声检查显示没有脉络膜积液。托吡酯与急性继发性闭角型青光眼有关，这是对该药物的一种特异反应。开具托吡酯处方的医生需要提醒患者注意这种潜在的威胁视力的特异反应。
