Neubauer Henning, Wirth Clemens, Ruf Katharina, Hebestreit Helge, Beer Meinrad
Department of Paediatric Radiology, Institute of Radiology, University Hospital Wuerzburg, Josef-Schneider-Straße 2, 97080 Wuerzburg, Germany.
Case Rep Pediatr. 2012;2012:527989. doi: 10.1155/2012/527989. Epub 2012 Jan 23.
Cystic fibrosis (CF) is one of the most common inherited diseases and is caused by mutations in the CFTR gene. Although the pulmonary and gastrointestinal manifestations of the disease remain in the focus of treatment, recent studies have shown expression of the CFTR gene product in skeletal muscle cells and observed altered intramuscular Ca(2+) release dynamics in CFTR-deficient animal models. Physical exercise is beneficial for maintaining fitness and well-being in CF patients and constitutes one aspect of modern multimodal treatment, which has considerably increased life span and reduced morbidity. We report on a case of acute muscle trauma resulting from excessive dumbbell exercise in a young adult with cystic fibrosis and describe clinical, laboratory and imaging characteristics of acute exercise-induced muscle injury.
囊性纤维化（CF）是最常见的遗传性疾病之一，由CFTR基因突变引起。尽管该疾病的肺部和胃肠道表现仍是治疗的重点，但最近的研究表明CFTR基因产物在骨骼肌细胞中表达，并在CFTR缺陷动物模型中观察到肌内钙（Ca2+）释放动力学改变。体育锻炼有助于维持CF患者的健康和幸福感，是现代多模式治疗的一个方面，多模式治疗显著延长了患者寿命并降低了发病率。我们报告了一例年轻成年囊性纤维化患者因过度哑铃锻炼导致急性肌肉创伤的病例，并描述了急性运动性肌肉损伤的临床、实验室和影像学特征。
